DTX-4

Trivial Name:DTX 4
CAS Registry Number: 162795-98-4
Source Organism:Prorocentrum lima
Formula: C66H104O30S3
Exact Mass: 1472.5756
Formula Weight: 1473.9
Production Method: Natural product
Storage/Shipping Conditions: -20oC

Mode of action:
Okadaic acid is a polyether from the dinoflagellate Prorocentrum lima that is the causative agent of diarrhetic shellfish poisoning (DSP).1 Okadaic acid acts as a non-phorbol ester type tumor promoter2 and as an inhibitor of protein phosphatases PP1 and PP2A.3 DTX 4 is a precursor to okadaic acid produced by Prorocentrum lima.4 DTX 4 is inactive both in vitro and in vivo and may serve as a water-soluble, non-toxic storage form of okadaic acid.5

Unit size: 25 µg - $ 498

1 Yasumoto, T. et al. Tetrahedron (1985) 41, 1019-1025. 2 Suganuma, M. et al. Proc. Nat. Acad. Sci. USA (1988) 85, 1768-1771. 3 (a) Takai, A. et al. FEBS Lett. (1987) 217, 81-84; (b) Haystead, T. A. et al. Nature (1989) 337, 78-81. 4 (a) Hu, T. et al. J. Chem. Soc. Chem. Commun. (1995) , 597-599; (b) Wright, J. L. C. et al. J. Am. Chem. Soc. (1996) 118, 8757-8758. 5 Windust, A. J. et al. Toxicon (1997) 35, 1591-1603.