[D-Asp3] Microcystin-LR

Trivial Name : [D-Asp3] Microcystin-LR, Desmethyl Microcystin-LR

Source Organism: Microcystis aeruginosa 
CAS Registry Number: 120011-66-7

Formula: C 48 H 72 N 10 O 12
Exact Mass: 980.53
Formula Weight: 981.15
Production Method: Natural product
Storage/Shipping Conditions: This material is packaged in glass vialsand is shipped with an ice pack. If prolonged storage is required, keep in atightly sealed container at -20oC

Toxicity : Toxic; Hepatotoxin; and Possible carcinogen

Mode of action:
Microcystins and Micropeptins are cyclic hybrid non-ribosomal peptide toxinsisolated from various cyanobacteria.1 They inhibit eukaryoticprotein phosphatases PP1 and PP2a and are selectively transported to the liver resulting in acute liver failure and tumor promotion.2

Unit size: 25 µg - $163

1 (a) Carmichael, W. W. et al. Toxicon (1988) 26, 971-973; (b) Rinehart, K. L. et al. J. Am. Chem. Soc. (1988) 110, 8557-8558. 

2 (a) MacKintosh, C. et al. FEBS Lett. (1990) 264, 187-192; (b) Chorus, I. et al. J. Toxicol. Env. Health B
(2000) 3, 323-347; (c) Zurawell, R. et al. J. Toxicol. Env. Health B (2005)8, 1-37.